A high beta hCG could indicate multiples twins or triplets , which would be confirmed through an ultrasound. One study found that median hCG levels on Day 13 after a fresh embryo transfer were for women with one baby and for women carrying twins.
There are other medical reasons that could be behind an unusually high beta hCG. Even though the data of outcomes from low beta hCG levels looks scary, remember that there are many normal, healthy pregnancies that start out with a low beta hCG. It could mean the embryo has a slower implantation process.
Try not to obsess too much with the hCG numbers. As stated above, the ultrasound findings are much more predictive of pregnancy outcomes than the hCG levels.
If you have concerns about your beta hCG numbers, always talk to your doctor. Yes, multiple pregnancies twins, triplets, etc. Talk to your doctor about the numbers and what they mean given your situation. However, if your hCG level is falling, it is likely that the implantation was not successful.
Your doctor will have you take additional blood tests until hCG is no longer detected to ensure that you have recovered and can move forward. If your hCG stays the same and does not drop to zero, your doctor will talk to you about options to intervene. One international study found the average beta hCG value was higher for female fetuses compared to males, but the results were not statistically significant.
Another study found that gender-related difference in HCG does exist as early as three weeks after fertilization, but that the difference is not strong enough to be used to predict fetal sex "because of the small proportion of pregnant women with serum HCG concentrations that are high or low enough to allow a prediction with high probability".
This is because fluid build-up from OHSS could dilute the blood levels. Although this happens, the good news is that research shows that the outcomes of these pregnancies remained comparable to those of IVF pregnancies without OHSS. Another study even showed that there is a lower rate of early miscarriage in the OHSS group 7.
Here are the expected hCG ranges in the first 18 weeks of pregnancy:. Because hCG levels vary a lot from pregnancy to pregnancy, there is no strict cutoff for determining viability. What does often indicate an impending miscarriage, however, are hCG levels that fail to double every 48 hours or that drop over time.
This nearly always indicates a failing pregnancy. It can also indicate an ectopic pregnancy—an pregnancy that has implanted somewhere other than the uterus. One final caveat: All of the above studies involved women undergoing IVF.
We cannot say whether these numbers apply to women undergoing IUI or who conceived naturally. Some but not all studies find that HCG levels are lower and less predictive of miscarriage after frozen as opposed to fresh embryo transfers. If you have had a first trimester ultrasound, you may wish to check out my post on miscarriage risk by week, by fetal heart rate, and by other risk factors like your age. Porat S, E. Early serum beta-human chorionic gonadotropin in pregnancies after in vitro fertilization: contribution of treatment variables and prediction of long-term pregnancy outcome.
Kim, J. Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET.
Kim, Y. PLoS One 12, Kumbak B, E. Serum oestradiol and beta-HCG measurements after day 3 or 5 embryo transfers in interpreting pregnancy outcome. Papageorgiou TC, E. Human chorionic gonadotropin levels after blastocyst transfer are highly predictive of pregnancy outcome.
Xue Y, E. Predictive value of early serum beta-hCG levels after single blastocyst transfer. Lambers MJ, E. Optimizing hCG cut-off values: a single determination on day 14 or 15 is sufficient for a reliable prediction of pregnancy outcome.
Journal of Assisted Reproduction and Genetics. As a former research scientist and proud mama of three little munchkins, I love digging into the research on all things baby-related and sharing it with my readers. View all posts by Amy Kiefer. I came across some articles that stated that the doubling time increases as the levels increase. After miu, the doubling time increases to three days, and after , the doubling time increases to over four days. Heart rate was , and it was measuring perfectly on target.
The moment all future mothers anxiously wait for following assisted reproduction treatment finally arrives, called the beta hcg wait. These days are tough, and after all the tests, injections and treatment, the wait feels even longer….
But after all that waiting finally comes the big moment. You take a pregnancy test and it comes back positive. Your heart starts to race and you go to the clinic where they order the Beta hCG hormone blood test , but your level is low. The doctor congratulates you, but is a bit wary …. A normal level is a good indicator that the pregnancy is viable. In these cases the patient will continue taking the same medication and the clinic will have the future mom return for her first ultrasound scan , generally two weeks after the pregnancy test.
It is during this ultrasound scan that a properly progressing pregnancy will be confirmed when the doctor visualises the gestational sac in the uterus, the embryo and its heartbeat.
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